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KMID : 0617219900010010082
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Duksung Bulletin Phamaceutical Sciences
1990 Volume.1 No. 1 p.82 ~ p.91
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Conjugation of 5-Fluorouracil and Methotrexate to Poly-L-Iysine
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Abstract
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Drug-macromolecule conjugates, i.e., 5-fluorouracil-1-acetyl-poly-L-lysine (FU-AA-poly-L-lys) and methotrexate-poly-L-lysine (MTX-poly-L-lys) have been synthesized.
The analyses of conjugates gave the molar ratio of FU-AA: Poly-L-lysine of 109:1 and MTX: poly-L-lysine of 16:1. The weight percent of FU-AA (as FU-CH_2CO)-in FU-AA-poly-L- lysine conjugate was 22.4％ and the one of MTX in MTX-poly-L-lysine was 13％.
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